The Third International Conference on Multiple Comparisons
(MCP2002)
Main Web Page: http://www.mcp-conference.org/2002/
Monday, August 5 to Wednesday, August 7, 2002
Please click on Speaker name(s) to get presentation overheads; click on title to get abstracts
Monday, August 5 |
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Session and Room |
Time |
Speaker, Session and Talk Title |
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8:30-10:00 |
Continental Breakfast |
MA1 Waterford-Lalique |
10:00-12:00 |
John Tukey Memorial Opening Session |
|
10:00-10:05 |
A. Tamhane (Northwestern Univ.) and P.
Westfall (Texas Tech Univ.): Welcome |
|
10:05-10:50 |
Tribute to John Tukey |
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10:05-10:20 |
H. Braun (Princeton Univ.): The Legacy of John Tukey: The Problem of Multiple Comparisons ... and Beyond |
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10:20-10:35 |
J. Heyse (Merck): John W. Tukey's Multiple Contributions to Statistics at Merck |
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10:35-10:50 |
Y. Benjamini (Tel Aviv Univ.): The scope of multiple comparisons according to J. W. Tukey |
|
10:50-11:00 |
Discussion |
|
11:00-11:50 |
B. Efron
(Stanford Univ.): Empirical Bayes and Multiple Comparisons
(John Tukey Memorial Keynote Speech) |
|
11:50-12:00 |
Discussion |
--- |
12:00-1:30 |
Lunch Break |
MP1-I Lalique |
1:30-3:10 |
Adaptive Designs I, Session Chair: C.
Jennison* (Univ. of Bath) |
|
1:30-2:00 |
S. Todd (Univ. of Reading): Issues in monitoring bivariate group sequential trials
(Invited Talk) |
|
2:00-2:20 |
C. Jennison* (Univ. of Bath) and B.
Turnbull: Group sequential tests with data-dependent
treatment allocation |
|
2:20-2:40 |
W. Brannath, P.Bauer*, M.Posch and W.
Maurer (Univ. of Vienna): Sequential tests for
noninferiority and superiority |
|
2:40-3:00 |
G. Wassmer (Univ. of Cologne): ADDPLAN 2002: A Software for Planning and Analysing an Adaptive Design |
|
3:00-3:10 |
Discussion |
MP1-II Waterford |
1:30-3:10 |
Partitioning and Closed Testing, Session
Chair: J. Hsu (Ohio State Univ.) |
|
1:30-2:00 |
H. Finner* and K. Strassburger (Univ. of
Duesseldorf): The partitioning principle: A powerful tool
in multiple decision theory (Invited Talk) |
|
2:00-2:20 |
J. Hsu (Ohio
State Univ.): The closed testing principle and the
partitioning principle |
|
2:20-2:40 |
G. Hommel* (Univ. of Mainz) and G.
Bernhard (Novartis): Two- and one-sided tests for a set of
linear contrast hypotheses |
|
2:40-3:00 |
J.
Schmeidler (Mt. Sinai School of Medicine): Improved
algorithms for closure |
|
3:00-3:10 |
Discussion |
--- |
3:10-3:30 |
Coffee Break |
MP2-I Lalique |
3:30-5:10 |
Multiple Endpoints, Session Chair: L.
Gould (Merck) |
|
3:30-4:00 |
A. Cohen* and H.Sackrowitz (Rutgers
Univ.): Multiple endpoints - Formulations and properties of
procedures (Invited Talk) |
|
4:00-4:20 |
M. Gonen, P.
Westfall*, and W. Johnson (Texas Tech Univ.): Bayesian
multiple testing for two-sample multivariate endpoints |
|
4:20-4:40 |
B. Logan (Medical College of Wisconsin): A cone order monotone version of the likelihood ratio test for
comparing two treatments on multiple endpoints |
|
4:40-5:00 |
A. Tamhane*
(Northwestern Univ.) and B. Logan: A
superiority-equivalence approach to one-sided tests on multiple endpoints |
|
5:00-5:10 |
Discussion |
MP2-II Waterford |
3:30-5:10 |
Advances in False Discovery Rate, Session
Chair: Y. Benjamini (Tel Aviv Univ.) |
|
3:30-4:00 |
S. Sarkar (Temple Univ.): Recent results on false discovery rate (Invited Talk) |
|
4:00-4:30 |
C. Genovese and L. Wasserman* (Carnegie
Mellon Univ.): A large sample approach to controlling
FDR (Invited Talk) |
|
4:30-5:00 |
D. Yekutieli* and Y. Benjamini (Tel Aviv
Univ.): False discovery
rate confidence intervals |
|
5:00-5:10 |
Discussion |
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5:30-7:00 |
Social Mixer |
Tuesday, August 6 |
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Session and Room |
Time |
Speaker, Session and Talk Title |
TA1-I Lalique |
8:30-10:10 |
Adaptive Designs II Session Chair: G. Chi
(FDA) |
|
8:30-9:00 |
G. Lan
(Pfizer): Repeated significance tests in adaptive sequential
designs (Invited Talk) |
|
9:00-9:20 |
Q. Liu (J&J Pharmaceutical R& D):
Multiplicity and the choice of alpha-spending in two-stage
designs |
|
9:20-9:40 |
J. Lawrence
(FDA): Changing the test statistic after an interim
analysis |
|
9:40-10:00 |
Q. Li* and M.
Huque (FDA): A general multiplicity adjustment approach and
its application to evaluating several independently conducted studies |
|
10:00-10:10 |
Discussion |
TA1-II Waterford |
8:30-10:10 |
MCPs for Interactions, Session Chair: C.
Hirotsu (Meisei Univ.) |
|
8:30-9:00 |
M. Aoshima (Univ. of Tsukuba): Sample size determination for multiple comparisons with
components of a linear function of mean vectors (Invited Talk) |
|
9:00-9:20 |
C. Hirotsu (Meisei Univ.): Comparing subjects according to their time profiles based on
repeated measurements |
|
9:20-9:40 |
L. Hothorn
(Univ. of Hannover): Demonstration of interlaboratory
similarity of dose-response assays by modification of interaction contrasts |
|
9:40-10:00 |
K. Ghosh*, S. Li (Merck): Multiple comparison procedures in testing qualitative
interaction |
|
10:00-10:10 |
Discussion |
--- |
10:10-10:30 |
Coffee Break |
TA2-I Lalique |
10:30-12:10 |
Multiplicity Issues in Clinical Trials: Challenges From the Regulatory
Point of View. Session Chair: K. Mahjoob (FDA) |
|
10:30-11:00 |
R. Sridhara*,
G. Chen, K. He and G. Chi (FDA): Problem of alpha
adjustment in studies with multiple primary endpoints - Evaluation of relationship between
endpoints (Invited Talk) |
|
11:00-11:20 |
P. Yang*, G.
Chen, and G. Chi (FDA): Controlling the false positive rate
due to multiple analyses |
|
11:20-11:40 |
G. Chen*,
Y-C Wang, and G. Chi (FDA): Multiplicity issues in sample
size re-estimation for active control non-inferiority trials |
|
11:40-12:00 |
T-H Ng (FDA): Issues of simultaneous tests for non-inferiority and superiority |
|
12:00-12:10 |
Discussion |
TA2-II Waterford |
10:30-12:10 |
Computing for MCPs, Session Chair: P.
Somerville (Univ. of Central Florida) |
|
10:30-11:00 |
F. Bretz* (Univ. of Hannover) and P.
Westfall: Power of closed test procedures (Invited
Talk) |
|
11:00-11:20 |
T. Miwa*
(National Institute for Agro-Environmental Sciences, Tsukuba, JAPAN), T. Hayter and S.
Kuriki: The efficient evaluation of multi-normal
distribution functions |
|
11:20-11:40 |
P. Somerville* (Univ. of Central Florida) and F.
Bretz: Stepup
and stepdown multiple hypotheses testing for the correlated |
|
11:40-12:00 |
A. Gill* and P. Singh (Panjab Univ.): Sample quasi ranges-based class of one sided tests and related
multiple comparisons |
|
12:00-12:10 |
Discussion |
--- |
12:10-1:30 |
Lunch Break |
TP1-I Lalique |
1:30-3:00 |
MCPs for Efficacy and Safety Testing,
Session Chair: M. Huque (FDA) |
|
1:30-1:50 |
J.
Heyse* and D. Mehrotra (Merck): Multiplicity
considerations in clinical safety analyses |
|
1:50-2:10 |
S. Basu (N. Illinois Univ.): Multiplicity in clinical safety data |
|
2:10-2:30 |
E. Biesheuvel* (Organon NV) and L.
Hothorn: Protocol-designed subgroup analysis in
multi-armed clinical trials: multiplicity aspects |
|
2:30-2:50 |
D. Bristol*
and N. Stouffer (Purdue Pharma LP): A stepwise maximum
modulus test with unequal variances |
|
2:50-3:00 |
Discussion |
TP1-II Waterford |
1:30-3:00 |
MCPs for Comparisons with Controls,
Session Chair: B. Logan (Medical College of Wisconsin) |
|
1:30-1:50 |
E. Solorzano and N. Dasgupta* (Washington
State Univ.): Comparing multiple treatments to a
positive control, in the presence of a negative control |
|
1:50-2:10 |
S-H Cheung* (Chinese University of Hong
Kong) and K.S. Kwong: Multiple comparisons with a control
in families with both one-sided and two-sided hypotheses |
|
2:10-2:30 |
M. Horn* (Institute of Medical
Statistics, Jena, Germany), and C. Dunnett: Power and sample size comparisons of some FWE and FDR
controlling step-down and step-up procedures in the many-one case |
|
2:30-2:50 |
C. Dunnett
(McMaster Univ.): Drug screening and the false discovery
rate |
|
2:50-3:00 |
Discussion |
--- |
3:00-3:30 |
Coffee Break |
TP2-I Lalique |
3:30-5:10 |
FDA/Industry Panel Discussion, Session
Chair: P. Westfall (Texas Tech Univ.): R. ONeill (FDA), George Chi (FDA), N. Geller
(NHLBI), David Jordan (Pharmacia/Upjohn), Surya Mohanty (Johnson & Johnson), Larry
Gould (Merck), Peter Bauer (Univ. of Vienna), and Chen-Sheng Lin (Bristol-Myers Squibb). A discussion of multiplicity aspects in a "real" Phase III clinical trial. The goal is to develop some degree of consensus
among industry, government, and academic statisticians concerning requirements and methods
for multiplicity management in typical clinical trials.
There will be plenty of time for questions, comments, and discussion from panelists
and from the audience. |
TP2-II Waterford |
3:30-5:10 |
Model Fitting and Simultaneous Inference,
Session Chair: Y. Benjamini (Tel Aviv Univ.) |
|
3:30-4:00 |
R. Beran (Univ. of California, Davis):Multiple Comparisons for Smoothed Fits to One-and Two-way
Layouts (Invited Talk) |
|
4:00-4:30 |
I. Johnstone* (Stanford Univ.), Y.
Benjamini, F. Abramovich and D. Donoho: False discovery
rates and the estimation of sparse normal means (Invited Talk) |
|
4:30-4:45 |
S. Kuriki (Institute of Statistical
Mathematics): Limiting null distribution of the
Jones-Sibson projection pursuit index and its approximation by the tube formula |
|
4:45-5:00 |
D. Donoho and J. Jin* (Stanford Univ.): Optimal adaptivity of Tukey`s higher criticism |
|
5:00-5:10 |
Discussion |
Wednesday, August 7 |
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Session and Room |
Time |
Speaker, Session and Talk Title |
WA1-I Lalique |
8:30-10:10 |
Analysis of DNA-Microarray Assays,
Session Chair: N. Geller (NHLBI) |
|
8:30-9:00 |
R. Simon (NIH): Multiple comparison issues in the design and analysis of
studies of DNA Microarray Gene Expression Profiles (Invited Talk) |
|
9:00-9:20 |
K. Pollard* and M. van der Laan (Univ. of
California, Berkeley): Parametric and nonparametric
methods to identify significantly differentially expressed genes |
|
9:20-9:40 |
S. Kropf*
(Otto von Guericke Univ.), J. Läuter, M.
Eszlinger: Multiple comparisons with gene expression arrays
using a data driven ordering of hypotheses |
|
9:40-10:00 |
G. Pennello (FDA): Screening for genes with differential expression in
microarray experiments: A Bayesian subset selection approach |
|
10:00-10:10 |
Discussion |
WA1-II Waterford |
8:30-10:10 |
MCPs in Simulation Experiments and Monte
Carlo Methods, Session Chair: B. Nelson (Northwestern Univ.) |
|
8:30-9:00 |
D. Goldsman (Georgia Tech): Random walk methods for analyzing the performance of
Bernoulli and multinomial selection procedures (Invited Talk) |
|
9:00-9:20 |
B. Nelson
(Northwestern Univ.): Asymptotic analysis of a fully
sequential selection procedure for steady-state simulation |
|
9:20-9:40 |
J. Boesel (The MITRE Corp.): Combinations of subset selection and indifference-zone
procedures to select the best of a large number of systems |
|
9:40-10:00 |
J. Opdyke
(Economic Consulting Group): Fast two-sample permutation
tests, even when one sample is large, that efficiently maximize power under conventional
Monte Carlo sampling |
|
10:00-10:10 |
Discussion |
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10:10-10:30 |
Coffee Break |
WA2-I Lalique |
10:30-12:10 |
Foundations, Bayesian Methods and Novel
Approaches, Session Chair: H. Finner (Deutsches Diabetes-Forschungsinstitut, Abteilung
Biometrie und Epidemiologie) |
|
10:30-11:00 |
J. Shaffer (Univ. of California,
Berkeley): Is the null hypothesis ever true? Correspondence between beliefs and multiple
comparison procedures (Invited Talk) |
|
11:00-11:20 |
J. Chen* and
S. Sarkar (Merck) A Bayesian Approach to Stepwise Simultaneous Testing |
|
11:20-11:40 |
C. Lewis* and D. Thayer (ETS): Multiple inferences for random effects |
|
11:40-12:00 |
Q. Liu (J&J Pharmaceutical R& D):
On the SMART principles for multiple comparisons |
|
12:00-12:10 |
Discussion |
WA2-II Waterford |
10:30-12:10 |
Selection Procedures and Screening
Experiments, Shanti S. Gupta Memorial Session,
Session Chair: J. Hsu (Ohio State Univ.) |
|
10:30-11:00 |
G. Giani*, H. Finner and K. Strassburger
(Univ. of Duesseldorf): Subset selection of good
populations: Partitioning principle, power control, and software (Invited Talk) |
|
11:00-11:20 |
G. Pan and T.
Santner* (Ohio State Univ.): Screening Procedures to
Identify Robust Product Designs Based on General Combined-Array Experiments |
|
11:20-11:40 |
W. Wang and D. Voss* (Wright State
Univ.): Control of error rates in adaptive analysis of
saturated factorial designs |
|
11:40-12:00 |
S. Gupta and D. Li* (Merck): On empirical Bayes procedures for selecting good populations in
positive exponential family |
|
12:00-12:10 |
Discussion |
--- |
12:10-1:30 |
Lunch Break |
WP1-I Lalique |
1:30-3:00 |
Multiple Dose Studies and Other Problems,
Session Chair: N. Dasgupta (Washington State Univ.) |
|
1:30-1:50 |
L. Shen (Sanofi-Synthelabo Research): A new method to evaluate drug effect in a multiple dose
clinical trial |
|
1:50-2:10 |
V. Berger (NCI): Improving the information content of clinical trial endpoints |
|
2:10-2:30 |
P. Somerville* (Univ. of Central Florida)
and W. Liu: Stepwise multiple tests for successive
comparison of treatment effects |
|
2:30-2:50 |
J-W Choi* and B. Nandram (NCHS/CDC): Measure of similarity between two groups with common variables |
|
2:50-3:00 |
Discussion |
WP1-II Waterford |
1:30-3:00 |
Genomics, Session Chair: L. Hothorn
(Univ. of Hannover) |
|
1:30-1:50 |
J. Troendle (NIH): Controlling the false discovery proportion or the number of
false discoveries with application to high-dimensional genomic |
|
1:50-2:10 |
J. Rogers*,
J. Hsu and S. Lin (Cereon Genomics): Applying the
partitioning principle to genome scans |
|
2:10-2:30 |
C. Sabatti*, S. Service and N. Freimer
(Univ. of California, Los Angeles): False discovery rate
and correction for multiple |
|
2:30-2:50 |
J. Chen and H. Hsueh* (National ChengChi
Univ.): Estimating the number of true null hypotheses in
multiple testing problems |
2:50-3:00 |
Discussion |