Programm

Program

Sunday, July 8, 2007
Short Courses (8:30 AM-12:30 PM)
Sam I	Introduction to Multiple Comparison Procedures Jason Hsu
Sam II	Adaptive Designs for Clinical Trials Werner Brannath, Frank Bretz
Short Courses (1:30 PM - 5:30 PM)
Spm I	Analysis of multiple endpoints Alex Dmitrienko
Spm II	Workshop on the Analysis of Microarray Data Katherine S. Pollard

Monday, July 9.
Time	Stream 1	Stream 2
AM1: 8:30 - 10:00	Charles Dunnett and Eckart Sonnemann Memorial Keynote Session:
	Multiple inference in medical research – an experience Peter Bauer Martin Posch - Opening of the Conference Wolfgang Schütz - Welcome from the Dean of the Medical University of Vienna Ajit Tamhane - Eulogy to Charles Dunnett Helmut Finner - Eulogy to Eckart Sonnemann Jason Hsu - Closing Remarks
Coffee break
AM2: 10:30 - 12:00	Adaptive Designs Chair: Willi Maurer	Bioinformatics/Genomics Chair: Alexander Ploner
	Prospective Strategies and Challenges to Adaptively Designing Genomic Biomarker Targeted Trials in Trials Sue-Jane Wang Adaptive model-based designs in clinical drug development Vlad Dragalin Exploring changes in treatment effects across design stages in adaptive trials Tim Friede, Robin Henderson Estimation in Adaptive Group Sequential Design Cyrus Mehta, Werner Brannath, Martin Posch	A New Hypothesis to Test Minimal Fold Changes of Gene Expression Levels Jen-pei Liu, Chen-Tuo Liao, Jia-Yan Dai Family-wise error on the directed acyclic graph of Gene Ontology Jelle Goeman, Ulrich Mansmann Testing Procedures on Comparisons of Several Treatments with one Control in a Microarray Setting Dan Lin, Ziv. Shkedy, Tomasz Burzykowski, Hinrich W.H. Göhlmann, An De Bondt, Tim Perera, On the Probability of Correct Selection for Large k Populations, with Application to Microarray Data Xinping Cui, Jason Wilson
Lunch
PM1: 1:30 - 3:00	Bioinformatics/Genomics Chair: Jason Hsu	Adaptive Designs Chair: Frank Bretz
	Multiple Testing Procedures with Applications to Genomics Sandrine Dudoit; van der Laan, Mark J. Involving biological information for weighing statistical error under multiple testing Anat Reiner-Benaim	Modified Weighted Simes Tests in Group Sequential Designs Willi Maurer Adaptive Designs with Correlated Test Statistics Heiko Götte, Andreas Faldum, Gerhard Hommel On the use of conventional tests in flexible, multiple test designs Franz Koenig, Peter Bauer, Werner Brannath Flexible group-sequential designs for clinical trials with treatment selection Nigel Stallard, Tim Friede
Coffee Break / Poster Session 1
PM2: 3:30 - 5:00	Multiple Endpoints Chair: Chihiro Hirotsu	Bioinformatics/Genomics Chair: Jen-pei Liu
	On Consequences of One-Sided Alternative Hypotheses for the Null Hypothesis Joachim Röhmel Multiple comparisons for ratios to the grand mean Ludwig A. Hothorn, G. Dilba Comparison of Methods for Estimating Relative Potencies in Multiple Bioassay Problems Gemechis Dilba Multiple hypothesis testing to establish whether treatment is Aldo Solari, Salmaso Luigi, Pesarin Fortunato	Across and Down in Large SNP Studies: the MAX test of Freidlin and Zheng vs SAS PROC CASECONTROL Dana Aeschliman, Marie-Pierre Dube Sample size calculation for microarray data analysis using normal mixture model Masaru Ushijima Estimating the proportion of true null hypotheses with the method of moments Jose Maria Muino, P. Krajewski Knowledge-based approach to handling multiple testing in functional genomics studies Adam Zagdanski, Przemyslaw Biecek, Rafal Kustra

Tuesday, July 10.
Time	Stream 1	Stream 2	Stream 3
AM1: 8:30 - 10:00	Theory and Foundations Chair: Ludwig Hothorn	Categorical Data / Nonparametrics Chair: Cyrus Mehta	Bioinformatics / Genomics / Other Chair: Nigel Stallard
AM1: 8:30 - 10:00	Aesthetics and power in multiple testing – a contradiction? Gerhard Hommel A general principle for shortening closed test procedures with applications Werner Brannath, Frank Bretz FDR-control: Assumptions, a unifying proof, least favorables configurations and FDR-bounds Helmut Finner, Thorsten Dickhaus, Markus Roters Asymptotic improvements of the Benjamini-Hochberg method for FDR control based on an asymptotically optimal rejection curve Thorsten Dickhaus, Helmut Finner, Markus Roters	A unified approach to proof of concept and dose estimation for categorical responses Bernhard Klingenberg Multiple Testing Procedures with Incomplete Data for Rank-based Tests of Ordered Alternatives. Paul Cabilio, Jianan Peng Adjusting p-values of a stepwise generalized linear model Chiara Brombin, Finos L., Salmaso L. A test procedure for random degeneration of paired rank lists Michael G. Schimek, Peter Hall, Eva Budinska	Non-negative matrix factorization and sequential testing Paul Fogel, S. Stanley Young, NISS (possibly speaker) Multiple Testing Procedures for Hierarchically Related Hypotheses Przemyslaw Biecek On the conservatism of the multivariate Tukey-Kramer procedure Takahiro Nishiyama, Takashi Seo Distribution Theory with Two Correlated Chi-Square Variables Anwar H Joarder
Coffee break
AM2: 10:30 - 12:00	Resampling based methods Chair: Sandrine Dudroit	Adaptive Designs Chair: Tim Friede	Screening and Selection Chair: Juliet Shaffer
AM2: 10:30 - 12:00	Resampling-Based Control of the False Discovery Rate under Dependence Michael Wolf, Joseph Romano, Azeem Shaikh To model or not to model Jason Hsu, Violeta Calian, Dongmei Li False discovery proportion control under dependence Yongchao Ge Resampling-Based Empirical Bayes Multiple Testing Procedure for Controlling the False Discovery Rate with Applications to Genomics Houston Gilbert, Sandrine Dudoit, Mark J. van der Laan	CONFIDENCE SETS FOLLOWING A MODIFIED GROUP SEQUENTIAL TEST Hans-Helge Müller, Nina Timmesfeld Unbiased estimation after modification of a group sequential design Nina Timmesfeld, Schäfer, Helmut, Müller, Hans-Helge Homogeneity of stages in adaptive designs Andreas Faldum Controversy? What controversy? - An attempt to structure the debate on adaptive designs Marc Vandemeulebroecke	On estimates of R-values in selection problems Andreas Futschik Screening for Partial Conjunction Hypotheses Ruth Heller, Benjamini, Yoav Exact simultaneous confidence bands for multiple linear regression over an ellipsoidal region Shan Lin, Wei Liu Stepwise confidence intervals for monotone dose-response studies Jianan Peng, Chu-In Charles Lee, Karolyn Davis
Lunch
PM1: 1:30 - 3:00	Error rates Chair: Ajit Tamhane	Normal theory, linear/non linear models Chair: Anthony Hayter	Closed testing and partitioning principle Chair: Gunnar Stefansson
PM1: 1:30 - 3:00	Control of Generalized Error Rates in Multiple Testing Joseph P. Romano Comparing mutliple tests for separating populations Juliet Shaffer A leave-p-out based estimation of the proportion of null hypotheses in multiple testing problems Alain Celisse Repeated significance tests controlling the False Discovery Rate Martin Posch, Sonja Zehetmayer, Peter Bauer	Simultaneous Inference for Ratios David Hare, Hare, David and John Spurrier Neglect of Multiplicity in Hypothesis Testing of Correlation Matrices Burt Holland Minimum area confidence set optimality for confidence bands in simple linear regression Wei Liu, A. J. Hayter Sch\'effe type multiple comparison procedure in order restricted randomized designs Omer Ozturk, Steve MacEachern	The multiple confidence procedure and its applications Tetsuhisa Miwa Gate-keeping testing without tears David Li, Mehrotra, Devan An Application of the Closed Testing Principle to Enhance One-Sided Confidence Regions for a Multivariate Location Parameter Michael Vock A Procedure to Multiple Comparisons of Diagnostic Systems Ana Cristina Braga, Lino A. Costa e Pedro N. Oliveira
Coffee Break / Poster Session 2
PM2: 3:30 - 5:00	Closed testing and partitioning principle Chair: Russ Wolfinger	Bioinformatics / Genomics Chair: A Lawrence Gould	Response Adaptive and Optimal Designs Chair: Sue-Jane Wang
PM2: 3:30 - 5:00	Multiple Testing of General Contrasts: Truncated Closure and the Extended Shaffer-Royen Method Peter H. Westfall, Tobias, Randall D. Powerful short-cuts for gatekeeping procedures Frank Bretz, Gerhard Hommel, Willi Maurer Simultaneous confidence regions corresponding to Holm's stepdown multiple testing procedure Olivier Guilbaud Compatible simultaneous lower confidence bounds for the Holm procedure and other closed Bonferroni based tests Klaus Strassburger, Frank Bretz	Detecting differential expression in microarray data: Outperforming the Optimal Discovery Procedure Alexander Ploner, Elena Perelman, Stefano Calza, Yudi Pawitan FLEXIBLE TWO-STAGE TESTING IN GENOME-WIDE ASSOCIATION STUDIES André Scherag, Helmut Schäfer, Hans-Helge Müller Sequential genome-wide association studies for pharmacovigilance Patrick Kelly FDR control for discrete test statistics Anja Victor, Scheuer C, Cologne J, Hommel G	Multiple treatment comparison based on a non-linear binary dynamic model Brajendra Sutradhar, Vandna Jowaheer On Multiple Treatment Effects in Adaptive Clinical Trials for Longitudinal Count data Vandna Jowaheer, Brajendra C. Sutradhar Multi-treatment optimal response-adaptive designs for continuous responses Atanu Biswas, Saumen Mandal On Identification of Inferior Treatments Using the Newman-Keuls Type Procedure Samuel Wu, Weizhen Wang; David Annis

Wednesday, July 11.
Time	Stream 1	Stream 2
AM1: 8:30 - 10:00	Bayesian methods/False discovery rate Chair: James Pan	Adaptive Designs Chair: Werner Brannath
AM1: 8:30 - 10:00	Bayesian adjusted inference for selected parameters Daniel Yekutieli A Bayesian Spatial Mixture Model for FMRI Analysis Brent Logan, Maya P. Geliazkova, Daniel B. Rowe, Prakash W. Laud A Bayesian screening method for determining if adverse events reported in a clinical trial are likely to be related to treatment A Lawrence Gould Exact calculations of expected power for the Benjamini-Hochberg procedure Deborah Glueck, Anis Karimpour-Fard, Lawrence Hunter, Jan Mandel and Keith E. Muller	Estimating the interesting part of a dose-effect curve: When is a Bayesian adaptive design useful? Frank Miller Sample size re-estimation and hypotheses tests for trials with multiple treatment arms Jixian Wang, Franz Koenig Adaptive Design in Dose Ranging Studies Based on Both Efficacy and Safety Responses Olga Marchenko, Prof. R. Keener, University of Michigan, Ann Arbor Adaptive seamless designs for subpopulation selection based on time to event endpoints Emmanuel Zuber, Werner Brannath, Michael Branson, Frank Bretz, Paul Gallo, Martin Posch, Amy Rac
Coffee break
AM2: 10:30 - 12:00	Bioinformatics Chair: Katherine S. Pollard	Others Chair: Sanat Sarkar
AM2: 10:30 - 12:00	Ranks of true positives in large scale genetics experiments Russell D. Wolfinger, Zaykin, Dmitri; Zhivotovsky, Lev; Czika, Wendy; Shao, Susan Multi-stage designs controlling the False Discovery or the Family Wise Error Rate Sonja Zehetmayer, Peter Bauer, Martin Posch Two-stage designs for proteomic and gene expression studies applying methods differing in costs Alexandra Goll, Bauer Peter Some insights into FDR and k-FWER in terms of average power and overall rejection rate Meng Du	A Weighted Hochberg Procedure Ajit Tamhane, Lingyun Liu Multiple Testing in Change-Point Problem with Application to Safety Signal Detection Jie Chen Sequentially rejective test procedures for partially ordered sets of hypotheses David Edwards, Jesper Madsen Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout Thomas Jaki, Martin J. Wolfsegger
Lunch
PM1: 1:30 - 3:00	Multiple endpoints problems Chair: Jie Chen	Error rates Chair: Klauss Strassburger
PM1: 1:30 - 3:00	Stepwise Testing of Multiple Dose Groups Against a Control With Ordered Endpoints James Francis Troendle A new method to identify significant endpoints in a closed test setting Carlos Vallarino, Joe Romano, Michael Wolf, Dick Bittman Proportion of true null hypotheses in non high-dimensional multiple testing problems: procedures and comparison Mario Walther, Claudia Hemmelmann; Rüdiger Vollandt An Exact Test for Umbrella Ordered Alternatives of Location Parameters: the Exponential Distribution Case Parminder Singh	Procedures Controlling Generalized False Discovery Rate Sanat Sarkar, Wenge Guo Effects of dependence in high-dimensional multiple testing problems Kyung In Kim, Mark A. van de Wiel A semi-parametric approach for mixture models: Application to local FDR estimation Jean-Jacques Daudin, A. Bar-Hen, L. Pierre, S. Robin Two new adaptive multiple testing procedures. Etienne Roquain, Gilles Blanchard
Coffee Break
PM2: 3:30 - 5:00	Clinical Trials Chair: Peter Westfall
PM2: 3:30 - 5:00	Multi-stage gatekeeping procedures with clinical trial applications Alex Dmitrienko, Tamhane, Ajit A unifying approach to non-inferiority, equivalence and superiority tests Chihiro Hirotsu Multiplicity-corrected, nonparametric tolerance regions for cardiac ECG features Gheorghe Luta, S. Stanley Young, Alex Dmitrienko Comparing treatment combinations with the corresponding monotherapies in clinical trials Ekkehard Glimm, Norbert Benda