V. Guiard (FBN Dummerstorf, Germany)

Multiple Test Problems in Detecting of Genes - a small overview

In order to detect quantitative trait loci (QTL), influencing a special trait, for every position of the chromosomes it will be tested whether there exists a QTL or not. For a simple situation, if the test statistic is considered as a function on the position on a chromosome, it varies according to the square of an Orenstein-Uhlenbeck diffusion process. For more complicated situations the overall error will be controlled by means of a permutation test. Both apperoaches assume the overall null hypothesis that there is no Gene influencing the trait of interest. For every inheritable trait there will by be at least one Gene on the genom. Therefore Weller etal applied the concept of the false discovery rate for detecting QTL.


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